L
O A D I N G

Scientific Production and Research Management



Research Activity Overview

SINERGIES Lab.

My research within the SINERGIES Lab. focuses on modeling decision support systems and operational research. They cover data extraction, learning, and modeling; the design of autonomous and/or intelligent methods and systems; and validation and recommendations in real-world application contexts.
Throughout my research career, both academic and industrial, I have been confronted with the increasing complexity of decision-making processes in hospitals and the healthcare system. These environments generate large amounts of data—medical, logistical, organizational—that require adapted tools to be effectively exploited, with the dual goal of improving care quality and system efficiency.


My research mobilizes contributions from Big Data, knowledge engineering, machine learning (notably reinforcement learning), and operational research to design decision support tools. I have collected and processed large volumes of data in various fields: medical imaging (especially for sacroiliac joints), monitoring of chronic pathologies, high-risk pregnancies, and geriatric risk prevention.
This constantly evolving data enriches my work on multivariate time series mining and predictive medicine. It has notably allowed me to develop an algorithm for the early detection of organ decompensation, capable of alerting up to 12 days before the event. This system is currently used by the ARS Pays de Loire in the PHILEMON project as well as in various experimental hospital projects.
The reliability of these results is based on rigorous methodologies validated by clinical trials, in partnership with Mutualité Française, the VyV group, several University Hospitals (Strasbourg, Besançon, Rouen), as well as international structures such as Rehabilitation Hospital No. 3 in Shanghai. These collaborations facilitate access to patients, medical expertise, and industrial valorization opportunities.
This work has led to several PhD theses, numerous scientific publications, and the deployment of a telemonitoring system within the framework of experiments conducted in connection with University Hospitals and home care structures.


Convinced that leading research structures is the engine of collective innovation, I coordinate multidisciplinary units to address the major healthcare challenges of tomorrow.

Responsibilities

Since 2015, I have been Deputy Director of the LNIT laboratory and then Deputy Director of SINERGIES since 2024 (150 members), born from the strategic merging of several units. In this capacity, I lead the scientific development of this multidisciplinary structure around three major axes: engineering for health, integrated and personalized care, and biomarkers and therapeutic targets. As the head of the UTBM site, I coordinate academic and industrial collaborations, both in France and internationally, and I lead the transversal actions and scientific policy of the laboratory.
My commitment is part of a strong dynamic of breaking down barriers between disciplines and bringing together fundamental research and concrete medical challenges.

Since 2019, I have also headed the O2S (Organization of Health Systems) team, composed of 8 permanent researchers and 5 associated collaborators across two sites, UTBM in Belfort and UMLP in Besançon. Specialized in operational research applied to health, this team has successfully federated structuring projects with a consolidated budget of €7.615 M for the 2025-2028 period, testifying to our ability to lead large-scale projects, build lasting synergies, and respond to national and European health priorities.


Convinced that doctoral supervision is an essential lever for transmission and international openness, I train researchers engaged in global scientific dynamics.

Supervision

My commitment to scientific supervision is long-term, with 22 PhD theses supervised or co-supervised between 1995 and 2025, totaling a cumulative supervision rate of 1150%. These theses were conducted in partnership with French universities (Strasbourg, Lyon 1, UFC, UHA) and international universities (Antonine University in Lebanon, University of Lomé in Togo, Cadi Ayyad University in Morocco), including one joint degree, two CIFRE theses (ALCATEL-LUCENT, ISYCARE Tech), and several competitive fundings (CSC, CONACyT, ANR, and industrial projects).
The supervised work has led to numerous scientific publications, and more than half of the defended doctors currently hold associate professor positions or permanent contracts, all having been qualified by the CNU, often in double sections.
Furthermore, I have supervised numerous Research Master's theses, engineering student projects, post-doctoral fellows, and engineers integrated into my research projects, representing a cumulative investment of 2800%. This support is part of a logic of excellence, transmission, and professionalization, at the heart of my academic action.


Convinced that academic research must be part of an open, collaborative, and high-impact dynamic, I am fully invested in expertise activities, international scientific cooperation, knowledge dissemination, and valorization.

Outreach

I develop scientific activities recognized at both national and international levels. I have been invited as a visiting professor to several renowned universities, including Columbia University (USA), Shanghai University (China), Antonine University (Lebanon), Cadi Ayyad University of Marrakech (Morocco), and AGH University of Science and Technology (Poland). These academic stays have strengthened my international partnerships, resulting in co-authored publications, joint research projects, and doctoral co-supervisions.
My expertise is regularly requested by evaluation agencies (ANR, ANRT, MESRS Algeria, NHS Italy, CNRST Morocco), in selection committees (Associate and Full Professors), or thesis monitoring. I actively participate in scientific and editorial committees as a reviewer, guest editor, or editorial board member, and I have chaired or co-organized several international conferences. Furthermore, my research work has led to concrete technological innovations, rewarded multiple times, and the creation in 2021 of the start-up ISYCARE Technology dedicated to optimizing home care. These contributions reflect a constant commitment to high-quality research, open to the world, connected to societal challenges, and focused on valorization.


Convinced that the most promising research projects are built at the crossroads of fundamental knowledge, strategic partnerships, and societal impact, I design and lead programs combining methodological innovation, interdisciplinary cooperation, and knowledge transfer to public and private actors

Projects

Since 2002, I have coordinated numerous programs combining methodological innovation and knowledge transfer. Below is a condensed selection of major projects:


Certified Projects

ISYCARE (2020)
Labeled by the cluste Véhicule Intelligent.
Partners: ISYCARE Technology, UTBM.
DIABETe (2018)
Labeled by the cluste AlsaceBiovalley.
Partners: CHRU Strasbourg, Activ Diab67, CENTICH, UTBM.

Institutional Research Projectss

ALISON++ (2025-2028)
Optimisation de la sédation en réanimation.
Funding: FEDER-Région BFC (4,8 M€).
Partners: CHRU Besançon, CISTEO Medical.
GESICA (2025-2028)
Prédiction des moyens de soins (Interreg FR-CH).
Funding: FEDER (5,6 M€).
Partners: CHRU Besançon, CHU Genève, UNIGE, CHUV Lausanne.
QVaDOM (2020-2023)
Télésurveillance et maintien à domicile.
Funding: FEDER-Région BFC (655 K€).
Partners: CHRU Besançon, UFC, ISYCARE Technology.
ALISON (2020-2023)
IA pour la mesure de l'analgésie.
Funding: Région BFC (206 K€).
Partners: CHRU Besançon, UTBM.
O2SaD (2019-2021)
Optimisation des Services et Soins à Domicile.
Funding: FRI BPI-Région BFC (258 K€).
Partners: UTBM.


Convinced that the most promising research projects are built at the crossroads of fundamental knowledge, strategic partnerships, and societal impact, I design and lead programs combining methodological innovation, interdisciplinary cooperation, and knowledge transfer to public and private actors.

Publications

My scientific production is at the interface of artificial intelligence, personalized medicine, critical information systems, and innovative health services. It relies on strong interdisciplinarity and lasting partnerships with hospital, academic, and industrial sectors.
Over the years, I have coordinated numerous applied research projects, supervised doctoral students on major societal issues, and contributed to the growth of concrete solutions in telemonitoring, care logistics, and predictive analysis.
This work is reflected in more than two hundred publications in international scientific journals, books, numerous chapters, and strong involvement in impactful partnership projects.
Below you will find a complete and structured presentation of my scientific and technological contributions.



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